a Record control number WOS:000348303600128

a ISSN 1940-5901

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WI140

b Item number .S65 2014

a Personal name Seyman, Derya.

a Title Soluble TRAIL levels decreased in chronic hepatitis C treatment with pegylated interferon alpha plus ribavirin: association with viral responses

h Medium Electronic Document

c Statement of responsibility, etc Derya Seyman, Arzu Didem Yalçın, Nefise Öztoprak, Gizem Esra Genç, Nevgun Sepin Özen, Filiz Kızılateş, Hande Berk, Saadet Gümüşlü.

b Name of publisher, distributor, etc E-Century Publıshıng Corp,

c Date of publication, distribution, etc 2014.

a Summary, etc The molecular mechanisms and pathogenesis of chronic hepatitis C (CHC) infection are unclear. Innate immune cells such as natural killer (NK) cells and dendritic cells are responsible from molecular mechanism of CHC. NK cell cytotoxicity such as TRAIL expression is important pathway for viral clearance. The aim of this study was to evaluate the relationship between HCV RNA and sTRAIL levels during the first 12 weeks of Peg-IFN alpha and ribavirin treatment. Twelve treatment naive patients with CHC treated with Peg-INF alpha and ribavirin were included in this study. Circulating sTRAIL and HCV RNA levels were measured at baseline, 4th and 12th week of treatment and their correlation was investigated. sTRAIL and HCV RNA levels decreased gradually with Peg-INF alpha plus ribavirin treatment. The differences were significant between day 0, 4th week and 12th week of treatment. The expression of sTRAIL was correlated with HCV RNA level at baseline, at 4th and 12th week of treatment (P = 0.021 P = 0.012, P = 0.001 respectively). IFN binds to its receptor on the infected hepatocyte surface during Peg-IFN alpha and ribavirin treatment. So the polarized phenotype of NK cell is not displayed and NK cell cytotoxicity such as TRAIL expression is blocked. We suggest that the decreased level of circulating sTRAIL may reflect increased binding to its ligand expressed on hepatocyte and decreased TRAIL production under the influence of Peg-IFN alpha plus ribavirin treatment. Therefore TRAIL may be probably a immunologically predictive factor such as HCV RNA during treatment.

a Topical term or geographic name as entry element Gastroenterology & Hepatology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

g Relationship information 2014, Vol.129, Issue:7, Issue:12, p.5650-5656

t Title Internatıonal Journal of Clınıcal and Experımental Medıcıne

x International Standard Serial Number 19405901